At-home Light Therapy to Improve Mood and Cognition

Full study title: Physiological Effect of Non-invasive Photobiomodulation on Cognition and Mood in Older Adults with Subjective Cognitive Impairment

What is the study about?

Photobiomodulation (PBM) is a type of light therapy that may help improve memory, thinking, and mood. This study will explore whether a 5-week at-home PBM treatment program can help older adults who have noticed changes in their memory or thinking abilities. To understand how the treatment may affect the brain, participants will complete memory tests, brain imaging, a nasal swab and a blood sample before and after the treatment. The results of this study may help researchers learn more about new, non-invasive ways to support brain health and healthy aging.

Eligibility - Who can participate?

• Age: 50-85 years old
• Healthy adult with subjective cognitive decline/concerns
• No major medical or neurological illness
• Are able to commit to and follow the treatment schedule

Time requirement

• Two in-person visits at Baycrest Hospital for approximately 3-4 hours. Both visits will involve memory and cognitive testing, an MRI scan, and a nasal swab and blood sample. The first visit will occur before the start of PBM therapy, and the second visit will occur after the end of PBM therapy.
• Daily 20-minute sessions of at-home PBM treatment for 5 weeks