Treating Major Depressive Disorder (MDD) with Cognitive Behavioural Therapy (CBT)
Full study title: Neuroimaging Markers of Midlife Depression and Cognitive Behavioural Therapy (CBT) in Caregivers
What is the study about?
Major depressive disorder is characterized by inflammation in the brain and is a key risk factor for developing Alzheimer’s Disease. This study looks at how inflammation in the brain responds to cognitive behavioural therapy in people living with major depressive disorder (MDD). This will involve imaging and blood sample collection, as well as remote therapy sessions.
Eligibility- Who can participate?
Participants must:
- Be 40-75 years of age, inclusive
- Meet diagnosis of a major depressive episode determined through a structured clinical interview conducted by the study clinical psychologist
- Be currently experiencing a major depressive episode of at least 3 months in length.
- Have the ability to understand and comply with the requirements of the study
Time requirement
- Two in-person visits at Baycrest Hospital for roughly 3 hours. This will involve 1 urine sample, 1 blood sample, and an MRI scan per visit
- Virtual therapy (CBT) for 50 minutes once a week, for 12-weeks
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Disclaimer
The listing of a study on the TDRA’s Research Studies Portal is for informational purposes only. The safety, efficacy or scientific validity of the studies listed here have not been evaluated by The Alzheimer Society of Toronto (AST) or the Toronto Dementia Research Alliance (TDRA). The TDRA is an academic coalition among the University of Toronto and Baycrest, the Centre for Addiction and Mental Health, Ontario Shores Centre for Mental Health Sciences, Sunnybrook Health Sciences Centre, and the University Health Network. The information collected will be kept and guarded by TDRA. Choosing to participate in a study is an important personal decision. Before you participate in a study, you should make sure you understand the risks and potential benefits and discuss all options with your health care provider(s).